Biologique Recherche

Biologique Recherche LA GRANDE CRÈME

The first of its kind in the world!

DNA research has finally made it possible to turn back the clock on all the ageing effects caused by environmental factors.

This science-driven cream is the fruit of years of research and development. It rejuvenates cells, improves the skin's elasticity and plumpness, reduces pigmentation and restructures the facial contours like no other.

La Grande Crème contains the greatest number of concentrated active ingredients ever used in a Biologique Recherche product. Epigenetic research (the study of genes) enabled scientists to identify the properties of EpigenActiv© in an anti-ageing skincare product. This peptide acts on Epidermal Growth Factor (EGF) receptors.
This pioneering cream, tackles all age-related phenomena and will leave your skin toned, smooth, protected, radiant and even.


  • Regenerating agents: EpigenActiv©, Milk Thistle Extract, Mimosa Extract
  • Structuring agent: Peony Extract
  • Firming agent: Complex of Elderflower, Chestnut Tree, and Myrobalan Leaf Extracts
  • Anti-wrinkle agents: Complex of Matrikines, Myorelaxant Peptides, and Carcinine
  • Anti-Spot agents: White Tea Extract, Watercress Sprout Extract, and Soy-Based Pure Genistein
  • Protective agents: Oligosaccharides, Pichia Anomala Extract, Wasabi Extract, Grape Juice Extract (enriched with δ-Viniferin)


  • Keeps cells younger for longer
  • Promotes cells renewal
  • Reverses DNA damage and prevents cutaneous ageing
  • Combats sagging skin and provide a lifting effect
  • Diminishes fine lines and wrinkles
  • Reduces pigmentation irregularities and provides radiance
  • Increases the skin resistance
  • Protects the cells against free radicals


  • Apply a hazelnut-sized amount of La Grande Crème in the morning and/or evening to the cleansed skin of entire face, neck, and décolleté. Massage the product into the skin, using upward strokes.
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